Statistical Evaluation of In Vivo Micronucleus Assays in Toxicology

Year: 2015       Vol.: 64       No.: 2      

Authors: John Closter F. Olivo

Abstract:

Several alternative statistical procedures have been suggested and published to statistically analyze the incidence of micronucleated polychromatic erythrocytes (MNPCs) among treatment groups, but no standard procedure has been singled out and exclusively recommended. In this study, the potential of TO2 to induce chromosomal damage is tested using both Poisson and quasi-Poisson models for the statistical evaluation of in vivo micronucleus (MN) assay. The genotoxic activity of T02 is assessed in the rodent bone marrow micronucleus test using male mice. Results show that MN frequencies are significantly elevated in mice exposed to any dose level of T02 administered orally in a single frequency of dose. Moreover, results indicate that T02 is tested to be a positive compound under the anticipated condition of the tests used.

Keywords: in vivo; micronucleus, MNPC; Poisson model; quasi-Poisson model; TO2

Download this article: